Mounjaro vs Wegovy

What are Mounjaro and Wegovy?

Both Mounjaro and Wegovy are prescription medicines that help with weight loss by mimicking hormones that regulate appetite and hunger. They work with your body’s internal signalling to help you feel fuller, eat less, and support a calorie deficit over time

Even though they have similar goals, they contain different active ingredients and work slightly differently once inside your body.

What is the main difference?

The major difference between Mounjaro and Wegovy is the active ingredient and how it interacts with hormone receptors in your body:

• Mounjaro contains tirzepatide. This targets two hormone pathways, including GLP-1 and another called GIP.

• Wegovy contains semaglutide, and focuses mainly on the GLP-1 pathway.

Because Mounjaro works on two pathways rather than one, many studies show it leads to slightly more weight loss for some people.

How they work in the body

Both treatments help regulate appetite by interacting with hormones your gut releases after you eat. This can:

• Signal your brain that you are full sooner

• Slow the rate your stomach empties

• Reduce cravings and overall appetite

• Support better blood sugar control in many cases

The difference is that:

• Wegovy focuses on the GLP-1 hormone pathway.

• Mounjaro targets GLP-1 plus another hormone called GIP, which may provide broader effects on metabolism and hunger.

Weight loss results you might expect

Clinical evidence suggests that both medications can support significant weight loss when taken correctly and under clinical care. On average:

• Mounjaro has shown average weight loss results around 20 percent or more in some studies.

• Wegovy has shown average weight loss around 14 to 20 percent, depending on the dose and trial.

Individual results vary based on dose, how long you take the medicine, your lifestyle, and how your body responds.

Side effects and safety

Both treatments share similar potential side effects because they act on similar hormone systems. Most people experience mild to moderate digestive symptoms as the body adjusts. These can include:

• Nausea

• Stomach discomfort

• Constipation or diarrhoea

Serious side effects are uncommon but possible and should always be discussed with a clinician before starting treatment.

Which one is right for you?

Neither medication is inherently better for everyone. The best choice depends on:

• Your weight loss goals

• Your medical history

• How your body responds to treatment

• Any other health conditions you have

For some people, Mounjaro’s dual hormone action may lead to stronger appetite control and greater weight loss. For others, Wegovy’s established track record and dosing profile may be the better match. Your clinician will help assess which option is safest and most suitable for your individual needs.

How Otto supports your treatment

At Otto, prescribing Mounjaro or Wegovy is never a quick transaction. We focus on safe, clinically guided treatment with ongoing monitoring. Your journey includes:

• Medical eligibility checks

• Pharmacist oversight and dose adjustments

• Side effect support

• Regular check-ins to help you stay on track

This support ensures your treatment is tailored and safe, helping you achieve sustainable results and make meaningful changes to your health.

Summary

Mounjaro and Wegovy are both GLP-1 based weight loss treatments that help reduce appetite and support a caloric deficit. The primary difference is that Mounjaro acts on two hormone pathways while Wegovy focuses on one, which may influence how much weight people lose. Both can be effective when used with clinical supervision and alongside lifestyle changes.